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rabbit anti total trka  (Cell Signaling Technology Inc)


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    Cell Signaling Technology Inc rabbit anti total trka
    Fig. 8 Effects of SCH and OHT on NGF-mediated <t>TrkA</t> and p75NTR signaling pathway. NGF induces TrkA signaling pathway to increase neuronal prolifera- tion. Pro-NGF, the precursor protein of NGF, can combine with p75NTR preferentially to enhance neuronal apopto- sis. CREB, cAMP response element-binding protein; JNK, C-Jun N-terminal kinase; NGF, nerve growth factor; OHT, overt hypothyroidism; p75NTR, p75 neurotrophin receptor; SCH, subclinical hypothyroidism; TrkA, tropomyosin-related kinase A
    Rabbit Anti Total Trka, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 95/100, based on 251 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/rabbit+anti+total+trka/TrkA+Antibody/pm33966253-76-26-31
    Average 95 stars, based on 251 article reviews
    rabbit anti total trka - by Bioz Stars, 2026-10
    95/100 stars

    Images

    1) Product Images from "Maternal Subclinical Hypothyroidism in Rats Impairs Spatial Learning and Memory in Offspring by Disrupting Balance of the TrkA/p75 NTR Signal Pathway."

    Article Title: Maternal Subclinical Hypothyroidism in Rats Impairs Spatial Learning and Memory in Offspring by Disrupting Balance of the TrkA/p75 NTR Signal Pathway.

    Journal: Molecular neurobiology

    doi: 10.1007/s12035-021-02403-z

    Fig. 8 Effects of SCH and OHT on NGF-mediated TrkA and p75NTR signaling pathway. NGF induces TrkA signaling pathway to increase neuronal prolifera- tion. Pro-NGF, the precursor protein of NGF, can combine with p75NTR preferentially to enhance neuronal apopto- sis. CREB, cAMP response element-binding protein; JNK, C-Jun N-terminal kinase; NGF, nerve growth factor; OHT, overt hypothyroidism; p75NTR, p75 neurotrophin receptor; SCH, subclinical hypothyroidism; TrkA, tropomyosin-related kinase A
    Figure Legend Snippet: Fig. 8 Effects of SCH and OHT on NGF-mediated TrkA and p75NTR signaling pathway. NGF induces TrkA signaling pathway to increase neuronal prolifera- tion. Pro-NGF, the precursor protein of NGF, can combine with p75NTR preferentially to enhance neuronal apopto- sis. CREB, cAMP response element-binding protein; JNK, C-Jun N-terminal kinase; NGF, nerve growth factor; OHT, overt hypothyroidism; p75NTR, p75 neurotrophin receptor; SCH, subclinical hypothyroidism; TrkA, tropomyosin-related kinase A

    Techniques Used: Binding Assay

    Related Articles

    Incubation:

    Article Title: Maternal Subclinical Hypothyroidism in Rats Impairs Spatial Learning and Memory in Offspring by Disrupting Balance of the TrkA/p75 NTR Signal Pathway.
    Article Snippet: The markers were separated at a constant 80 V for 30 min, and the proteins were separated at a constant 120 V for 1 h. After electrophoresis, the proteins were transferred to polyvinylidene difluoride membranes (Millipore, Billerica, MA, USA) at a constant of 100 V for 1.5 h. Nonspecific binding was blocked using a mixture of Tris-buffered saline and 0.05% Tween-20 with the skimmed milk powder, except for phospho-C-Jun N-terminal kinase (p-JNK), phospho-cAMP response element-binding protein (p-CREB), phospho-extracellular signal-regulated kinase (p-ERK) and phospho-tropomyosin receptor kinase A (p-TrkA) that were blocked with bovine serum albumin (BSA). .. The membranes were incubated overnight at 4 °C with the following antibodies: rabbit anti-NGF (1:1000 dilution; Abcam, ab52918, Cambridgeshire, UK); rabbit anti-proNGF (1:1000 dilution; Sigma-Aldrich, P5498); rabbit anti-total TrkA (1:1000 dilution; Cell Signaling Technology 2505S, USA); rabbit anti-p-TrkA (1:1000 dilution; Abcam, ab1445); rabbit anti-total ERK (1:1000 dilution; CST4695S); rabbit anti-pERK (1:2000 dilution; CST4370S); rabbit anti-total CREB (1:1000 dilution; CST9197S); rabbit anti-p-CREB (1:1000 dilution; CST9198S); rabbit anti-p75NTR (1:1000 dilution; CST8238S); rabbit anti-p53 (1:1000 dilution; CST32532S); rabbit anti-total JNK (1:1000 dilution; CST9252S); rabbit anti-p-JNK (1:1000 dilution; CST4668S); rabbit anti-Bax (1:1000 dilution; CST2772S); and rabbit anti-cleaved caspase-3 (1:1000 dilution; CST9664S). .. The blots were incubated for 1.5 h with horseradish-peroxidase-conjugated secondary antibody (1:5000 dilution; ZB2301, Beijing, China) and developed by chemiluminescent western blotting (ALPHAVIEW, version 1.3; Protein Simple Inc., San Jose, CA, USA).

    Article Title: Maternal Subclinical Hypothyroidism in Rats Impairs Spatial Learning and Memory in Offspring by Disrupting Balance of the TrkA/p75 NTR Signal Pathway
    Article Snippet: The markers were separated at a constant 80 V for 30 min, and the proteins were separated at a constant 120 V for 1 h. After electrophoresis, the proteins were transferred to polyvinylidene difluoride membranes (Millipore, Billerica, MA, USA) at a constant of 100 V for 1.5 h. Nonspecific binding was blocked using a mixture of Tris-buffered saline and 0.05% Tween-20 with the skimmed milk powder, except for phospho-C-Jun N-terminal kinase (p-JNK), phospho-cAMP response element-binding protein (p-CREB), phospho-extracellular signal-regulated kinase (p-ERK) and phospho-tropomyosin receptor kinase A (p-TrkA) that were blocked with bovine serum albumin (BSA). .. The membranes were incubated overnight at 4 °C with the following antibodies: rabbit anti-NGF (1:1000 dilution; Abcam, ab52918, Cambridgeshire, UK); rabbit anti-proNGF (1:1000 dilution; Sigma-Aldrich, P5498); rabbit anti-total TrkA (1:1000 dilution; Cell Signaling Technology 2505S, USA); rabbit anti-p-TrkA (1:1000 dilution; Abcam, ab1445); rabbit anti-total ERK (1:1000 dilution; CST4695S); rabbit anti-p-ERK (1:2000 dilution; CST4370S); rabbit anti-total CREB (1:1000 dilution; CST9197S); rabbit anti-p-CREB (1:1000 dilution; CST9198S); rabbit anti-p75 NTR (1:1000 dilution; CST8238S); rabbit anti-p53 (1:1000 dilution; CST32532S); rabbit anti-total JNK (1:1000 dilution; CST9252S); rabbit anti-p-JNK (1:1000 dilution; CST4668S); rabbit anti-Bax (1:1000 dilution; CST2772S); and rabbit anti-cleaved caspase-3 (1:1000 dilution; CST9664S). .. The blots were incubated for 1.5 h with horseradish-peroxidase-conjugated secondary antibody (1:5000 dilution; ZB2301, Beijing, China) and developed by chemiluminescent western blotting (ALPHAVIEW, version 1.3; Protein Simple Inc., San Jose, CA, USA).



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    Fig. 8 Effects of SCH and OHT on NGF-mediated <t>TrkA</t> and p75NTR signaling pathway. NGF induces TrkA signaling pathway to increase neuronal prolifera- tion. Pro-NGF, the precursor protein of NGF, can combine with p75NTR preferentially to enhance neuronal apopto- sis. CREB, cAMP response element-binding protein; JNK, C-Jun N-terminal kinase; NGF, nerve growth factor; OHT, overt hypothyroidism; p75NTR, p75 neurotrophin receptor; SCH, subclinical hypothyroidism; TrkA, tropomyosin-related kinase A
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    https://www.bioz.com/product/rabbit+anti+total+trka/TrkA+Antibody/pm33966253-76-26-31
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    Image Search Results


    Fig. 8 Effects of SCH and OHT on NGF-mediated TrkA and p75NTR signaling pathway. NGF induces TrkA signaling pathway to increase neuronal prolifera- tion. Pro-NGF, the precursor protein of NGF, can combine with p75NTR preferentially to enhance neuronal apopto- sis. CREB, cAMP response element-binding protein; JNK, C-Jun N-terminal kinase; NGF, nerve growth factor; OHT, overt hypothyroidism; p75NTR, p75 neurotrophin receptor; SCH, subclinical hypothyroidism; TrkA, tropomyosin-related kinase A

    Journal: Molecular neurobiology

    Article Title: Maternal Subclinical Hypothyroidism in Rats Impairs Spatial Learning and Memory in Offspring by Disrupting Balance of the TrkA/p75 NTR Signal Pathway.

    doi: 10.1007/s12035-021-02403-z

    Figure Lengend Snippet: Fig. 8 Effects of SCH and OHT on NGF-mediated TrkA and p75NTR signaling pathway. NGF induces TrkA signaling pathway to increase neuronal prolifera- tion. Pro-NGF, the precursor protein of NGF, can combine with p75NTR preferentially to enhance neuronal apopto- sis. CREB, cAMP response element-binding protein; JNK, C-Jun N-terminal kinase; NGF, nerve growth factor; OHT, overt hypothyroidism; p75NTR, p75 neurotrophin receptor; SCH, subclinical hypothyroidism; TrkA, tropomyosin-related kinase A

    Article Snippet: The membranes were incubated overnight at 4 °C with the following antibodies: rabbit anti-NGF (1:1000 dilution; Abcam, ab52918, Cambridgeshire, UK); rabbit anti-proNGF (1:1000 dilution; Sigma-Aldrich, P5498); rabbit anti-total TrkA (1:1000 dilution; Cell Signaling Technology 2505S, USA); rabbit anti-p-TrkA (1:1000 dilution; Abcam, ab1445); rabbit anti-total ERK (1:1000 dilution; CST4695S); rabbit anti-pERK (1:2000 dilution; CST4370S); rabbit anti-total CREB (1:1000 dilution; CST9197S); rabbit anti-p-CREB (1:1000 dilution; CST9198S); rabbit anti-p75NTR (1:1000 dilution; CST8238S); rabbit anti-p53 (1:1000 dilution; CST32532S); rabbit anti-total JNK (1:1000 dilution; CST9252S); rabbit anti-p-JNK (1:1000 dilution; CST4668S); rabbit anti-Bax (1:1000 dilution; CST2772S); and rabbit anti-cleaved caspase-3 (1:1000 dilution; CST9664S).

    Techniques: Binding Assay